Radiosensitizer ppt to pdf

Radiosensitizers and biological modifiers in radiotherapy. The oxygen effect resistance to chemotherapy and hypoxic cytoxins. Clinical trial results were disappointing overall, except in selected sites, most notably, head and neck cancer. Increased understanding of the molecular mechanisms underlying cancer. Hypoxic cell sensitisers nine different drugs have reached clinical evaluation misonidazole, metronidazole, benznidazole, desmethylmisonidazole etanidazole, pimonidazole nimorazole, ornidazole rsu1069 25.

Pdf converter is a online webbased document to pdf converter software. A free powerpoint ppt presentation displayed as a flash slide show on id. Tumor hypoxia reduces radio sensitivity in vitro and in vivo. New preclinical strategies for characterization and development of anticancer drugs. It is estimated that approximately 2040% of patients with malignant neoplasia will develop brain metastasis during their disease 1,2. Whether youre writing for radio, print, tv or the internet, a lot of the same basics apply. Radar communication ppt pdf radar seminar and ppt with pdf report. Ppt stereochemistry powerpoint presentation free to. Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in.

Radiotherapy rt is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Management of oropharyngeal cancer in the hpv era arash o. Follow these instructions to set the print quality of the pdf. Appendix a radio communication basics 1263 vlf lf mf hf vhf uhf shf ehf l s c x k u k 3 khz 30 khz 300 khz 3000 khz 30 mhz 300 mhz 3000 mhz 30 ghz 300 ghz 3 mhz 3 ghz source. Radio music powerpoint template is a free music powerpoint template with a waveform effect created in photoshop and using a headset for your slides. Well oxygenated cells partial pressure of oxygen or po, 10 mm jigare approximately 2. Radiosensitizer of rapidly proliferating cells through incorporation into dna during s phase. No clear evidence of clinical efficacy has been established to date. Brain metastases bm represent a major health problem in patients with cancer. It is sometimes also known as a radiation sensitizer or radioenhancer. In this section, we summarize the common nanomaterial.

Uptake results in decrease or removal of the shoulder of the radiation survival curve. Hypoxic cell radiosensitizers the first candidate to satisfy these criteria was misonidazole 26. Microrna621 acts as a tumor radiosensitizer by directly. Conclusion aguix might be used for mrguidance t1 acquisitions boosted radiation therapy first clinical trial in progress for multiple brain metastases. Department of radiation oncology, national cancer centre, 11 hospital drive, singapore169610, singapore. When we focus on interests or criteria for a decision then we can work to find agreement on something that could meet as much of the groups interests as possible. We did a multicentre, controlled, randomised trial. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. These lesions, whose incidence is increasing due to the improvement of primary cancers management, represent the most frequent intraaxial brain tumors. Oxygen best known and most general radiosensitizer the slopes of survival curves for cells exposed to sparsely ionizing radiation in hypoxia and in well oxygenated environments differ by about a factor of 3 the oxygen effect. One of the promises of nanoparticle np carriers is the reformulation of promising therapeutics that have failed clinical development due to pharmacologic challenges. Local tumor failure is the cause of 40% to 60% of cancer deaths and may occur in 60% to 80% of cancer patients at the time of death. Radiosensitizers and radioprotectors for effective radiation therapy.

The application of radiotherapy in hepatocellular carcinoma hcc is limited due to the low tolerance of normal liver cells for radiation and inherent radiation resistance in hcc. Thus, understanding the mechanism of action of a radiosensitizer. Revival of the abandoned therapeutic wortmannin by. Writing for radio the basics good writing is good writing. Clarity, good organization of your thoughts and themes, and a vocabulary that your listenersreadersviewers will understand are all important. Nitroglycerin is a commonly used vasodilator used in angina pectoris or heart failure, which has been proposed as a potentially valuable adjuvant drug in nonsmall cell lung cancer nsclc treatment. With the use of radiosensitizers and radioprotective agents, the course of radiotherapy has improved the sensitization of tumor cells and. The goal of radiation therapy is to achieve maximum tumor cell killing while minimizing injury to normal tissues therapeutic ratio. Enantiomers have the same physical properties and cannot be separated by normal. Oxygen is the definitive hypoxic cell radiosensitizer, the large differential radiosensitivity of oxic vs hypoxic cells being an attractive factor. Radiosensitizers, radioprotectors, and radiation mitigators raviraj j. Request pdf synthesis of pegylated ferrocene nanoconjugates as the radiosensitizer of cancer cells radiation is one of the most widely used methods for cancer diagnosis and therapy. These 2 treatments are synergistic in laboratory studies. To determine if the mtor inhibitor cci779 can sensitize head and neck squamous cell carcinoma hnscc to radiotherapy xrt and compare the radiosensitizing effects to cisplatin with its known considerable toxicity.

In particular, gold nanoparticles show promise in the advancement of cancer treatments. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating dna damage and producing free radicals. Examples include the fluoropyrimidines, gemcitabine and. Treatment decision for ib2 cervical cancer, limiting the number of different treatment modalities is recommended to limit toxicity the preferred approach is definitive chemoradiation nccn v3. Under print quality paper pdf, set the desired quality to an option of your choice. New preclinical strategies for characterization and. Here we demonstrate proof of the principle of using nps to revive the clinical potential of abandoned. Gu and colleagues found that the mir621 andor setdb1 axis could improve the radiosensitivity of hcc cells via activating the p53signaling pathway. Xrays and gamma rays are routinely used photons in radiation therapy to treat various cancers. At least one report of recall pneumonitis in a patient who had previously received radiation. And radar engineering, 3rd edition, umesh publication, 2003, pp. Neurosurgical and radiosurgical decision making in brain. However, current nanomedicine research has been focused on the delivery of established and novel therapeutics. This algorithm has been developed for md anderson using a multidisciplinary approach considering circumstances particular to md andersons specific patient population, services and structure, and clinical information.

Different photosensitizers are administered intravenously, orally, or topically and are retained for longer in neoplastic compared with normal cells, thus requiring a delay between administration and light irradiation. Mucosal tissue, also known as mucosa or the mucous membrane, lines all body passages that communicate with the air, such as the. Digital comprehensive summaries of uppsala dissertations from the faculty of medicine 78. This colon cancer in the elderly ppt presentation gives an introduction to factors and conditions associated with the colon cancer in elderly along with appropriate guidelines for screening and surveillance for the early detection of cancer. Inhibitors of apoptosis iaps limit the effectiveness of radiation in nonsmall cell lung cancer nsclc. Synthesis of pegylated ferrocene nanoconjugates as the. Introduction to increase the efficacy of chemoradiation and decrease its toxicity in normal tissue, a new concept is proposed, local radiosensitizer delivery, which combines triggered release of a radiosensitizer from thermosensitive liposomes with local hyperthermia and radiotherapy. Several strategies have been exploited to develop highly effective and. Colon cancer in the elderly powerpoint presentation is one of medicpresents medical powrpoint presentations.

Gold nanoparticles exhibit very unique physiochemical and optical properties, which now are extensively studied in range of medical diagnostic and therapeutic applications. Principal mechanism of action is mimicry of oxygens ability to fix free radical damage caused by exposure to radiation and some toxic chemicals. Polarity wavelength frequency amplitude phase these characteristics are defined by the laws of physics. Conventional chemotherapeutics are currently being used in conjunction with radiation therapy to increase its effectiveness. Save powerpoint presentations as pdf files office support. Colon cancer in the elderly powerpoint presentation. Due to the ability of the particles to increase the dose, free radicals are created from the energy absorbed by the particles.

Off ice of technology assessment, 1991, based on richard g. Radiosensitizers and biological modifiers in radiotherapy dr. Clinical phase i trial dose 1 dose 2 dose 3 dose 4 dose 5 15mgkg 30mgkg 50mgkg 75mgkg 100mgkg in progress aapm 2016 sancey l. At one point, we all have to make ppt of any topic and. Chemical radiosensitization elahe ghasemloy may2014 3. Radio transmission is the property of its rightful owner. Not only can nanoparticles be used to treat cancer they can be used to increase drug delivery. Ppt radio transmission powerpoint presentation free to. However, the potential for olaratumab to act as a radiosensitizer has yet to be examined, despite the frequent use of adjuvant rt in high risk sts. Pdf emerging strategies of nanomaterialmediated tumor. When people focus on individual preferences it can lead us into difficulties since each member normally has a fixed set of preferences.

Ijrobp, 2016 aggregate image features from the bulk tumor assuming tumor is well mixed clonal evolution causes regional differences in a tumor. Comparison of radiosensitizing effects of the mtor. Triggered radiosensitizer delivery using thermosensitive. Bnct has the potential to selectively target these infiltrating tumor cells. Cellular pathways in response to ionizing radiation and. Download as ppt, pdf, txt or read online from scribd. Current advances and future directions rajamanickam baskar1,2, kuo ann lee 1, richard yeo and khengwei yeoh1, 1. Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer. Introduction mucositis occurs when cancer treatments break down the rapidly divided epithelial cells lining the gastrointestinal tract which goes from the mouth to the anus, leaving the mucosal tissue open to ulceration and infection. A radiosensitizer is an agent that makes tumor cells more sensitive to radiation therapy. Boron neutron capture therapy bnct history preclinical. The optimal time delay is determined by the maximum concentration of the photosensitizer in tissue and this varies among photosensitizers. Between january, 1992, and december, 1999, of 1485 patients treated with primary radiotherapy alone, 1476 eligible patients were randomly assigned five n726 or six n750 fractions per week at the same total dose and fraction number 6668 gy in 3334 fractions to all tumour sites except welldifferentiated t1 glottic tumours, which.

The topoisomerase1 inhibitor, topotecan, has direct activity against neuroblastoma and acts as a radiation sensitiser. In conclusion, mir621 enhanced the radiosensitivity of hcc cells and activated the p53signaling pathway via inhibiting the expression of setdb1. Gould, allocation of the radio frequency spectrum, ota contractor report. The oxygen effect has driven the evolution of radiosensitization from initial. Here, key aspects of this concept were investigated in vitro i the effect of hyperthermia on the enhancement. Uncertainties and limitations in adaptive radiotherapy. Prostate cancer is the second most commonly diagnosed cancer in american. The nonporphyrinbased photosensitizer hypericin is a natural pigment derived from hypericum plants with the ability to selectively target tumors and minimal dark toxicity. Adapt plan to patientspecific changes that are unaccounted for in initial plan art techniques range in sophistication. Photon beams carry a low radiation charge and mass.